A 9-year-old girl is brought to the physician by her mother for a 1-month history of skin changes to the right forehead and periorbital region. She has acute lymphoblastic leukemia in remission and received her last dose of chemotherapy 4 months ago. Which of the following is the most likely explanation for this patient’s findings?

A) Bacterium
B) DNA virus
C) Stevens-Johnson syndrome
D) RNA virus
E) Toxic epidermal necrolysis

An 8-month-old boy is evaluated in hospital for a violaceous region that appears to be growing on the trunk. It was present as a faint mark since birth, but appears to have rapidly grown over the past month. Physical examination shows a 10×14-cm violaceous region on the trunk. Laboratory studies show:

Hemoglobin                                                    15 g/dL
Leukocytes                                                       8,000/μL
Platelets                                                            90,000/μL
Prothrombin time                                       13 seconds
Partial thromboplastin time                 30 seconds
Bleeding time                                                 9 minutes

Which of the following is the most likely explanation for this patient’s findings?

A) Cherry hemangioma
B) Kasabach-Merritt syndrome
C) Pyogenic granuloma
D) Stewart-Treves syndrome
E) Strawberry hemangioma

A 27-year-old woman at 39 weeks’ gestation presents to the obstetrician for an antenatal appointment. Her pregnancy has otherwise been unremarkable. She takes a daily multivitamin.

Which of the following is the most likely diagnosis?

A) Acute fatty liver of pregnancy
B) Intrahepatic cholestasis of pregnancy
C) Pemphigoid gestationis
D) Pruritic urticarial papules and plaques of pregnancy
E) Stevens-Johnson syndrome

A 26-year-old male is brought in by ambulance following a skiing accident in which he sustained bilateral comminuted fractures of the femurs requiring intramedullary rod stabilization. Platelet count is 90,000/μL. A photograph of his axillary region is shown.

Which of the following is the most likely explanation for this patient’s findings?

A) Cryoglobulinemia
B) Immune thrombocytopenic purpura
C) Fat embolism
D) Lichen planus
E) Kaposi sarcoma

A 29-year-old man comes to the physician for a follow-up appointment. His neck area is shown.

Which of the following is most likely to be seen in this patient?

A) Decreased serum cortisol
B) Decreased serum growth hormone
C) Decreased serum insulin
D) Increased binding of cutaneous IGF-1 receptors
E) Increased melanin production

A 24-year-old man comes to the physician for a 3-week history of a rash on his elbows. Cutaneous biopsy shows IgA deposition at the dermal papillae.

Which of the following is most likely to be seen in this patient?

A) Crypt abscesses
B) Flattening of the intestinal villi
C) Lipid droplets within enterocytes
D) Normal bowel biopsy
E) Skip lesions

A 4-year-old boy is brought to the physician by his mother for a high fever and lethargy for the past 24 hours. He has also developed skin lesions on his legs during this time.

Which of the following is most likely to be seen in this patient?

A) Deficiency of adenosine deaminase
B) Deficiency of C1q
C) Deficiency of cell-mediated immunity
D) Deficiency of mucosal immunoglobulin
E) Deficiency of total hemolytic complement

A 41-year-old woman comes to the physician for a follow-up appointment.

Which of the following is most likely to be seen in this patient?

A) Dysphagia
B) Hypocalcemia non-responsive to supplementation
C) Hypothyroidism
D) Tetany
E) Tremor

A 42-year-old man is evaluated in hospital.

Which of the following is most likely to be seen in this patient?

A) Antibodies against post-synaptic nicotinic receptors
B) Hepatic vein thrombosis
C) Hypothyroid state
D) Increased serum sodium
E) Reactive arthritis

Which of the following is most likely to be seen in this patient?

A) Aniridia
B) Coloboma
C) Hypothyroidism
D) Lipoma
E) Recurrent pneumonia