A 43-year-old woman comes to the physician for a follow-up appointment.

Which of the following is most likely to be seen in this patient?

A) Anti-Smith antibodies
B) Eburnation
C) Family history of type II diabetes
D) IgG antibody against the Fc region of IgM
E) Pannus

A 3-year-old boy is brought to the pediatrician for a follow-up appointment. He has a history of Staph and Strep infections. He appears notably fairer skinned than his 6-year-old sister.

Which of the following is the most likely explanation for this patient’s findings?

A) Adenosine deaminase deficiency
B) Glucocerebrosidase deficiency
C) Impaired phagolysosomal fusion
D) Leukocyte adhesion disruption
E) Tyrosine kinase deficiency

A 26-year-old woman comes to the physician for a follow-up appointment. She recently had a miscarriage and wants to discuss options for future care.

Which of the following is the most likely to be seen in this patient?

A) Anti-cyclic citrullinated peptide antibodies
B) Anti-histone antibodies
C) Increased partial thromboplastin time
D) Increased platelet count
E) Syphilis

A 34-year-old woman, G1P0, at 34 weeks gestation comes to the physician for a 1-week history of progressive yellowing of the eyes, fatigue, fever, and RUQ pain. She recently returned from visiting her family in Tibet. Four days later, her transaminases are markedly elevated. Partial thromboplastin time is elevated. Serum bile acids are normal. She does not report itchy skin. She undergoes Caesarean section and a liver transplantation. Which of the following is the most likely explanation for this patient’s presentation?

A) Acute hepatitis A infection
B) Intrahepatic cholestasis of pregnancy
C) Intravenous drug use
D) Shift from Th1 to Th2 immunity
E) Stimulation of CD8 immunity

A 4-year-old boy is brought to the physician by his mother for a high fever and lethargy for the past 24 hours. He has also developed skin lesions on his legs during this time.

Which of the following is most likely to be seen in this patient?

A) Deficiency of adenosine deaminase
B) Deficiency of C1q
C) Deficiency of cell-mediated immunity
D) Deficiency of mucosal immunoglobulin
E) Deficiency of total hemolytic complement

A 4-year-old boy is brought to the physician for a follow-up examination. He has a history of bacterial sepsis one year ago and 3 pneumonias since roughly 7 months of age. Which of the following is the most likely cause of the patient’s pathology?

A) Adenosine deaminase deficiency
B) Deficiency of mucosal immunoglobulin
C) Impaired cell-mediated immunity
D) Impaired phagolysosomal fusion
E) Tyrosine kinase deficiency

A 6-year-old boy is brought to physician by his parents for recurrent infections since early infancy. He has had multiple episodes of otitis media and pneumonia requiring antibiotics, and his parents report frequent episodes of diarrhea. Physical examination shows diffuse eczematous rash involving the flexural surfaces and trunk with areas of excoriation. The infant bruises easily, and his parents note frequent nosebleeds and prolonged bleeding after heel sticks. Which of the following is the most likely explanation for this patient’s presentation?

A) Chediak-Higashi syndrome
B) Hyper IgM syndrome
C) IgA deficiency
D) Job syndrome
E) Wiskott-Aldrich syndrome

A 9-year-old girl is brought to the physician by her mother for a 3-day history of small red spots on her shoulders and chest. She has no past medical history apart from a viral infection a couple weeks ago. Hemoglobin is 14 g/dL. Prothrombin time is 12 seconds. Partial thromboplastin time is 34 seconds. Bleeding time is 9 minutes. Leukocytes are 8,000/μL. Glucose is 88 mg/dL fasting. Which of the following is most immunologically similar to this patient’s condition?

A) Arthus reaction
B) Graves disease
C) Malar rash
D) Rhus dermatitis
E) Urticaria

A 22-year-old woman comes to the physician for a 1-day history of swelling of her hands and lips. She has had many such episodes in the past. The swelling is usually non-pitting and non-pruritic. Her right hand is shown.

Which of the following is the most likely explanation for this patient’s findings?

A) Decreased bradykininase activity
B) Increased degranulation
C) Increased high molecular weight kininogen cleavage
D) Increased histamine release
E) Increased recruitment of eosinophils

A researcher is evaluating different vaccines during a study about converting T-independent vaccines into T-dependent ones. Which of the following is the most likely focus of this researcher’s evaluation?

A) Diphtheria
B) Haemophilus influenzae type B
C) Hepatitis B
D) Mumps-Measles-Rubella
E) Rotavirus
F) Tetanus