A 45-year-old man comes to the physician for a follow-up appointment.

Which of the following is most likely to be seen in this patient?

A) APC gene mutation
B) C-MYC gene mutation
C) Hashimoto thyroiditis
D) High-grade hepatocellular carcinoma
E) Polycystic kidneys

A) Conjugated hyperbilirubinemia
B) Hematuria + flank mass
C) Hematuria + no flank mass
D) Intercellular bridges
E) Serum sodium of 125 mEq/L

A 54-year-old woman is evaluated in hospital. She has a long smoking history. A biopsy specimen is shown.

Which of the following is most likely to be seen in this patient?

A) Direct hyperbilirubinemia
B) Hematuria without flank mass
C) High serum calcium
D) Low serum sodium
E) Painful flank mass

A 47-year-old man is evaluated in hospital following a 2-week history of darkening of his urine. He reports no recent illnesses.

Which of the following is most likely to be seen in this patient?

A) Anti-Hu antibodies
B) Insulin resistance
C) Serum calcium of 12 mg/dL
D) Serum sodium of 125 mEq/L
E) Urinary specific gravity of 1.030

A 31-year-old woman comes to the physician for a follow-up appointment. She has a history of recurrent flares of joint pain and low platelets. Today she presents with two small mouth ulcers. Her prior HLA-B27 screening was negative. Serum creatinine and BUN are mildly elevated. Which of the following is most likely to be seen in this patient?

A) Anti-cyclic citrullinated peptide antibodies
B) Anti-microsomal antibodies
C) Decreased serum C3
D) IgM targeting the Fc region of IgG
E) Type II hypersensitivity

A) Autoimmunity
B) Deficiency of erythrocyte spectrin
C) Deficiency of NADPH production
D) Inhibition of ferrochelatase and δ-ALA dehydratase
E) Loss of lymphoid organ

A 53-year-old woman is recovering in hospital 24 hours after undergoing a left-sided lumpectomy. HER2/neu (ERBB2) analysis is negative.

Which of the following is most likely to be seen in this patient?

A) t(8;14) translocation
B) Activation of proto-oncogene
C) Hemolytic anemia (warm)
D) Galactocele
E) Neutrophilia

A 53-year-old man comes to the physician for a follow-up appointment. He takes no medications. The results of his bone scan are shown.

Which of the following is the most likely explanation for this patient’s findings?

A) Avascular necrosis
B) Osteopenia
C) Osteopetrosis
D) Primary hyperparathyroidism
E) Prostate cancer

A 39-year-old man is brought in by ambulance following a motor vehicle accident. His blood pressure is 70/20. There is marked jugular venous distention. Heart sounds are distant. Which of the following is most likely to be seen in this patient?

A) Bounding pulsus
B) Delayed carotid upstroke
C) Paradoxical pulse
D) S3
E) S4

A 39-year-old man comes to the physician for a follow-up appointment. He has a history of cystic fibrosis. A high-resolution CT of the chest is shown.

Which of the following is most likely to be seen in this patient as a result of these findings?

A) Copious foul-smelling sputum
B) Decreased alveolar capillary surface area
C) Increased pulmonary capillary wedge pressure
D) Increased Reid index
E) 6-month history of dry cough with dry inspiratory crackles