Audio Qbank – HY USMLE Q #458 – Internal medicine / Pathology

A 65-year-old man comes to the physician because of progressive weakness in both legs for the past 6 months. He has difficulty standing up from a chair and going up stairs. He finds it easier to stand up from a chair if he rocks back and forth first. He has also had a 7-kg weight loss during this time. He has smoked two packs of cigarettes daily for 45 years. Physical examination shows weakness of hip flexion and knee extension. A Babinski sign is absent. A chest x-ray shows a mass in the left lower lobe. Laboratory studies show:

Erythrocyte sedimentation rate (ESR)                                                 Elevated
Creatine kinase (CK)                                                                                       Normal

Which of the following is the most likely location of this patient’s abnormality?

Anterior horn
Muscle
Myoneural junction
Peripheral axon
Spinal cord