A 6-year-old girl is brought to the pediatrician for a follow-up examination. She has had recurrent urinary tract infections since birth. Laboratory studies show:
Hemoglobin 9 g/dL
MCV 75 μm3
Leukocytes 5,200/mm3 (lymphocytes 30%)
Platelets 210,000/mm3
Which of the following is the most likely explanation for these findings?