A 59-year-old man comes to the physician for a 2-day history of painful swelling of his left big toe. Physical examination shows several gouty tophi over the elbows bilaterally. Serum creatinine is 1.2 mg/dL. The most appropriate pharmacologic therapy to reduce frequency of episodes of this patient’s condition has which of the following mechanisms of action?
Decreased synthesis of prostaglandin
Disruption of microtubule assembly
Disruption of microtubule disassembly
Enhanced urinary excretion of organic acid
Inhibition of oxidation
