A 29-year-old man is admitted to hospital for a 2-day history of fever and chills. He has history of IV drug use. Temperature is 103 F. A 3/6 holosystolic murmur is auscultated at the 4th intercostal space in the left mid-clavicular line. Blood cultures are obtained and IV antibiotics are commenced. 48 hours later, the patient complains that the “room is spinning.” An agent that inhibits which of the following is the most likely explanation for these findings?
30S
50S
Dihydrofolate reductase
DNA gyrase
D-Ala-D-Ala
P450-mediated demethylation
