A 21-year-old woman comes to the physician for a 6-month history of recurrent migraines. She takes no medications apart from occasional ibuprofen and sumatriptan. Blood pressure is 140/90. The most appropriate next step in pharmacologic therapy for this patient will demonstrate which of the following combinations of effects?
↓ Systemic vascular resistance; ↓ Cardiac output
↓ Systemic vascular resistance; ↑ Cardiac output
↑ Systemic vascular resistance; ↓ Cardiac output
↑ Systemic vascular resistance; ↑ Cardiac output
↔ Systemic vascular resistance; ↔ Cardiac output
