A 15-year-old girl comes to the physician for recurrent nosebleeds and heavy menses. Her father also has history of nosebleeds. Laboratory studies show:
Hemoglobin 12 g/dL
Platelets 400,000/μL
Bleeding time 8 minutes
Prothrombin time 12 seconds
Partial thromboplastin time 38 seconds
Which of the following is the most likely explanation for these findings?
Antibodies against glycoproteins IIb/IIIa
Deficiency of clotting factor
Deficiency of bridging molecule
Inability to cleave von Willebrand factor multimers
Reduction in erythrocyte spectrin
