A 39-year-old woman comes to the physician for a routine health maintenance examination. She has a 10-year history of rheumatoid arthritis managed with multiple medications. Pulmonary function testing shows a normal FEV1/FVC. Chest x-ray shows mild reticulonodularity bilaterally. An agent that inhibits which of the following is the most likely explanation for this patient’s presentation?
Calcium channels
Cyclooxygenase
Dihydrofolate reductase
NFκB
TNF-α
