A 4-year-old boy is brought to the physician by his mother for a 1-week history of increased thirst and a 2-kg weight loss. Respiratory rate is 20. There is decreased skin turgor. Serum glucose is 600 mg/dL. Which of the following is the most likely explanation for this patient’s findings?
Deposition of amyloid and reduced cell mass
Large beta-cells and nuclei
Lymphocytic infiltration
Marked atrophy and fibrosis
Non-enzymatic glycosylation of basement membranes
