A 55-year-old man who underwent a lung transplantation one year ago for cystic fibrosis presents to the physician for a follow-up examination. Blood pressure is 170/100 and has been gradually increasing over the past year. Serum creatinine is 2.1 mg/dL. Which of the following pharmacologic agents is most likely responsible for this patient’s presentation?
Adriamycin
Bleomycin
Cyclophosphamide
Cyclosporine
Methotrexate
Rituximab
Sirolimus
Tacrolimus