A 45-year-old woman comes to the physician for a follow-up appointment. She has Hodgkin lymphoma that was treated with 4 months of doxorubicin, bleomycin, vincristine, and dacarbazine that ended 6 months ago. A chest x-ray is shown. Vitals are normal. There is no jugular venous distention or peripheral edema. Pulmonary capillary wedge pressure is 13 mmHg (NR 4-12). Her father died of COPD at the age of 55. Which of the following is most likely to have prevented this patient’s findings?
Early cessation of bleomycin with no change in daily dosage
Early substitution of dacarbazine for busulfan
Reduced daily dose of bleomycin with maintenance of duration
Reduced duration of adriamycin with maintenance of dosage
Serial administration of purified alpha-1 antitrypsin
