A 9-year-old boy is brought to the physician for a one-month history of fatigue. He has no past medical history or recent illnesses. Laboratory studies show a mild normochromic normocytic anemia. An eosin-5-maleimide test is positive. His father has a history of splenectomy and cholecystectomy. An abnormality of which of the following is most likely to be seen in this patient?
Cytoskeleton; autosomal heterozygous mutation
Cytoskeleton; autosomal homozygous mutation
Cytoskeleton; X-linked
Enzyme (glycolytic); autosomal heterozygous mutation
Enzyme (glycolytic); autosomal homozygous mutation
Enzyme (glycolytic); X-linked
Enzyme (non-glycolytic); autosomal heterozygous mutation
Enzyme (non-glycolytic); autosomal homozygous mutation
Enzyme (non-glycolytic); X-linked
Factor deficiency; autosomal heterozygous mutation
Factor deficiency; autosomal homozygous mutation
Factor deficiency; X-linked
No specific defect
