A 41-year-old woman comes to the physician because of a 1-year history of gradually progressive fatigue, weight gain, and cold intolerance. Her menses used to be 28 days and regular. For the past 6 months, they have grown increasingly heavy and unpredictable. She also reports recent difficulty concentrating and mild constipation. Physical examination shows dry skin and a mildly enlarged, firm thyroid gland. Laboratory studies show an increased TSH and low free T4. Anti-microsomal antibodies are positive. A fine-needle aspiration biopsy is performed to confirm the diagnosis. Which of the following histologic findings is most consistent with this patient’s diagnosis?
Aggregates of multinucleated giant cells and disrupted follicles
Amyloid deposition in the stroma derived from calcitonin
Branching papillae with nuclear grooves and inclusions
Lymphocytic infiltration with germinal center formation
Scalloping of colloid in hyperplastic follicles
Amyloid deposition in the stroma derived from calcitonin
Branching papillae with nuclear grooves and inclusions
Lymphocytic infiltration with germinal center formation
Scalloping of colloid in hyperplastic follicles
