A 6-year-old boy is evaluated for recurrent viral infections, including multiple episodes of influenza and respiratory syncytial virus (RSV), over the past two years. He has no significant bacterial or fungal infections. Physical examination is unremarkable, and his growth parameters are within normal limits. Genetic testing reveals a defect in a gene for TAP proteins. Which of the following best describes the immunologic consequence of this patient’s condition?
A) Decreased CD4+ T cell activity and increased basophil response
B) Decreased CD4+ T cell activity and increased neutrophilic chemotaxis
C) Decreased CD8+ T cell activity and increased natural killer (NK) cell activity
D) Decreased function of B cells
E) Decreased neutrophil recruitment
