A 22-year-old woman comes to the physician for a 1-day history of swelling of her hands and lips. She has had many such episodes in the past. The swelling is usually non-pitting and non-pruritic. Her right hand is shown.
Which of the following is the most likely explanation for this patient’s findings?
A) Decreased bradykininase activity
B) Increased degranulation
C) Increased high molecular weight kininogen cleavage
D) Increased histamine release
E) Increased recruitment of eosinophils
