A 31-year-old woman comes to the physician because of a 2-month history of an intractable need to move her legs and feet at night in bed. This has awoken her husband from sleep on numerous occasions and they have started sleeping in separate rooms. Hemoglobin is 10 g/dL. MCV is 72 fL. Vitals are normal. Which of the following is the most likely explanation for this patient’s presentation?
A) Decreased tyrosine hydroxylase activity
B) Decreased glutaminergic activity on the striatum
C) Decreased subthalamic nucleus activity
D) Increased globus pallidus internus activity
E) Parkinson disease
