A 45-year-old man comes to the physician for a follow-up appointment. Two weeks ago, his blood pressure was measured at 150/95. His BMI is 23. He is physically activate and does not smoke or drink. Repeat blood pressure measurement today is 150/95. The physician discusses possible commencement of hydrochlorothiazide. Which of the following is most likely to be seen in this patient as a result of commencement of this pharmacotherapy?
A) Blockade of early-DCT apical antiporter
B) Blockade of late-DCT apical symporter
C) Decreased serum bicarbonate
D) Hypercalciuria
E) Increased distal potassium secretion
