HY USMLE Q #1626 – Hematology

A 53-year-old woman is evaluated in hospital for a 6-month history of fatigue, lymphadenopathy, and easy bruising. Leukocyte count is 80,000/μL, with 89% lymphocytes. Hemoglobin is 9 g/dL. A Coombs test is positive.

Which of the following is most likely to be seen in this patient?

A) CD5/23 positivity
B) CD10 + TdT positivity
C) Intravascular hemolysis
D) t(9;22)
E) t(15;17)

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