A 19-year-old woman presents to the GP concerned about a yellowish nodule over her left Achilles tendon. Biopsy shows dermal foamy histiocytes. Her serum total cholesterol concentration is 420 mg/dL. A serum lipoprotein electrophoresis is performed and shows a high fraction of LDL. Which of the following is the most likely mechanism for this patient’s disorder?
Absence of hepatic LDL receptors
Deficiency of apolipoprotein C-II
Deficiency of hepatic LDL receptors
Deficiency of lipoprotein lipase
Increased hepatic production of VLDL
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Cut-to-the-chase Answer (0:51):
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HY USMLE Answer (4:42):
