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HY points about each drug followed by a quiz at the end
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Alemtuzumab
MOA of alemtuzumab? –> answer = monoclonal antibody against CD52.
Two main uses for alemtuzumab? –> answer = chronic lymphocytic leukemia (CLL) + multiple sclerosis (MS).
- “Alymtuzumab” –> chronic lymphocytic leukemia
Bevacizumab
MOA of bevacizumab? –> answer = monoclonal antibody against vascular endothelial growth factor (VEGF).
Two important uses for bevacizumab? –> answer = colorectal cancer + neovascular macular degeneration.
Rituximab
MOA of rituximab? –> answer = monoclonal antibody against CD20 on B cells.
Important use for rituximab? –> answer = Hodgkin lymphoma.
Rituximab is associated with ↑ risk of which opportunistic infection? –> answer = progressive multifocal leukoencephalopathy (PML), caused by JC polyoma virus.
- Natalizumab (monoclonal antibody against alpha-4 integrin in the treatment of MS) also notably increases the risk.
Trastuzumab
MOA of trastuzumab (Herceptin)? –> answer = monoclonal antibody against HER2/neu.
Main use of trastuzumab? –> breast cancer that has HER2/neu positivity.
Notable toxicity of trastuzumab? –> answer = cardiotoxicity.
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