Microbiology pharm – Hepatitis C drugs

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HY points about each drug followed by a quiz at the end

Hepatitis C

Ledipasvir, Ombitasvir, Velpatasvir

OVALOmbitasvir, Velpitasvir, -Asvir, Ledipasvir

MOA of Ledipasvir, Ombitasvir, Velpatasvir?

  • Inhibit NS5A, which is a phosphoprotein used in RNA replication.

Sofosbuvir, Dasabuvir

MOA of Sofosbuvir, Dasabuvir?

  • Inhibit NS5B, which is an RNA-dependent RNA polymerase.

Grazoprevir, Simeprevir

MOA of grazoprevir, simeprevir?

  • Inhibit NS3/4A, which is a viral protease.

1. MOA of Ledipasvir?

2. MOA of sofosbuvir?

3. MOA of grazoprevir?

4. MOA of dasabuvir?

5. MOA of ombitasvir?

6. MOA of simeprevir?

7. MOA of velpatasvir?

8. What is NS5A?

 
 
 

9. What is NS5B?

 
 
 

10. What is NS3/4A?

 
 
 

11. Name three drugs that inhibit NS5A.

12. Name two drugs that inhibit NS5B.

13. Name two drugs that inhibit NS3/4A.