Audio Qbank – Q144 – A 69M with heart failure

 

A 69-year-old man with heart failure is commenced on spironolactone. Which of the following is the most direct effect of administering this agent?

 

  Decreased binding of aldosterone to its receptor in the cortical collecting duct
  Decreased binding of aldosterone to its receptor in the medullary collecting duct
  Decreased binding of angiotensin II to its receptor on vascular endothelium
  Direct antagonism of aldosterone in plasma
  Direct antagonism of angiotensin II in plasma

 

Cut-to-the-chase Answer (0:58):
HY USMLE Answer (4:07):