A 50-year-old man with cystic fibrosis undergoes a bilateral lung transplant. Two months later he reports experiencing increased thirst and urination. Fasting glucose is 135 mg/dL. BMI is 22. Blood pressure is 120/80. Serum creatinine is 1.9 mg/dL. Physical examination shows normal gingiva and dentition. The patient does not report increased hair growth. A renal biopsy is shown.
It is concluded that this patient’s presentation is the result of one of his medications. Which of the following combinations is the most likely binding site and immunologic effect of this agent?
Binds FK-506; ↓ Responsiveness to IL-2
Binds FK-506; ↑ Responsiveness to IL-2
Binds FK-506; ↓ Transcription of IL-2
Binds FK-506; ↑ Transcription of IL-2
Binds mTOR; ↓ Responsiveness to IL-2
Binds mTOR; ↑ Responsiveness to IL-2
Binds mTOR; ↓ Transcription of IL-2
Binds mTOR; ↑ Transcription of IL-2
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Cut-to-the-chase Answer (0:54):
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HY USMLE Answer (6:23):
