A 52-year-old man with type II diabetes mellitus is brought to the emergency department for a 12-hour history of fever, confusion, and pain of his right leg. Vitals are: temperature 103F, HR 120, RR 20, BP 90/60. Laboratory studies show elevated blood urea nitrogen, creatinine, and hepatic transaminases. A photograph of the patient’s leg is shown.
Blood cultures shows gram-positive cocci in chains. The causal organism produced a toxin that resulted in the patient’s condition via which of the following mechanisms?
ADP ribosylation of adenylyl cyclase
Binding of CD14 (TLR-4)
Cleavage of 60S ribosomal subunit
Inhibition of elongation factor 2
Interaction with MHC-II and T-cell receptor
Phospholipase (α toxin) production
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Cut-to-the-chase Answer (0:38):
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HY USMLE Answer (8:56):
