A 2-year-old boy is brought to the physician for a follow-up examination. He has had five severe skin infections with S. aureus since birth; there has been no pus formation at the infection sites. Laboratory studies show persistent leukocytosis despite absence of infection. Dental examination shows erythematous, edematous gums. Which of the following is the most likely mechanism for this patient’s presentation?
Deficiency of adenosine deaminase
Deficiency of CD40 ligand
Deficiency of complement protein C7
Deficiency of LFA-1/CD18 integrin
Impaired conversion of hydrogen peroxide to hypochlorous acid
Impaired generation of reactive oxygen species
