A 16-year-old boy is brought to the physician for a one-month history of occasional bloody mucoid stools. He has no past medical history. Vitals are within normal limits. His mother has plaque psoriasis. Laboratory studies are shown:
Hemoglobin 10.5 g/dL
WBC 11,000/μL
ESR Elevated
In addition to NSAIDs and corticosteroids, a monoclonal antibody is considered as part of this patient’s treatment regimen. The molecular target of this latter pharmacologic therapy is most saliently responsible for which of the following?
Antibody isotype class-switching
Hypothalamic temperature set-point alteration
Macrophage secretion of IL-12
Tight junction permeability
T-lymphocyte activation
