Audio Qbank – HY USMLE Q #441 – Renal / Pharm

A 35-year-old man comes to the physician because of a 3-week history of excessive thirst and frequent urination. Physical examination shows dehydration. BMI is 20. Fasting laboratory studies show:

Serum glucose                                                        94 mg/dL
Serum ADH (vasopressin)                               High
Serum osmolality                                                  High
Urine osmolality                                                    Low

Which of the following is the most appropriate pharmacologic therapy for this patient?

Acetazolamide
Desmopressin
Ethacrynic acid
Hydrochlorothiazide
Spironolactone