A 38-year-old woman comes to the physician for a one-week history of severe headache, neck soreness, and photophobia. She has history of Hodgkin disease for which she has been receiving chemo- and radiotherapy. Temperature is 101 F. Results of a lumbar puncture are shown.
Glucose Low
Protein Elevated
Leukocytes Elevated (neutrophils 10%; monocytes 90%)
Erythrocytes None
The mechanism of action of the most appropriate pharmacologic therapy inhibits which of the following?