A 61-year-old man with biventricular heart failure and hypertension is commenced on furosemide therapy for the management of his peripheral edema. Four days later, the edema is not fully resolved. A pharmacologic agent with which of the following mechanisms of action is most appropriate to add to this patient’s regimen?
Blocks α-adrenergic receptors
Decreases collecting duct luminal permeability to sodium
Decreases collecting duct aquaporin insertion
Inhibition of calcium channels within vascular smooth muscle
Inhibition of distal convoluted tubule sodium/chloride symport
