Audio Qbank – HY USMLE Q #470 – Renal / Family Medicine

A 10-year-old boy is brought to the physician because of a 12-month history of wetting the bed at night. He has had increased thirst and urinary frequency during this time. The episodes occur every 2-3 weeks and last 1-2 days. There is no bed-wetting between episodes. His parents divorced one year ago. He is at the 97th percentile for weight and 60th percentile for height.  Laboratory studies show:

Serum glucose                                                                                        80 mg/dL
Urine glucose                                                                                          Negative
Urine protein                                                                                          Negative
Urine specific gravity                                                                         1.015

Which of the following is the most likely explanation for these findings?

β-islet cell apoptosis with ensuing fibrosis
Diminution of hypothalamic production of vasopressin
Impaired sensitivity of medullary collecting duct V2 receptors
Increased aquaporin insertion
Increased water consumption