A 39-year-old man comes to the physician for a 1-day history of severe pain, warmth, and swelling of his right knee. Two days ago he partook in a kickboxing tournament. Temperature is 99 F, HR 85, BP 115/70. Physical examination shows a right knee that is erythematous and warm to palpation. Arthrocentesis is performed. Analysis of joint aspirate shows a leukocyte count of 17,000/μL with 90% neutrophils and calcium pyrophosphate crystals. Which of the following is the most appropriate next step in management?
Acetaminophen
Allopurinol
Ceftriaxone and trimethoprim/sulfamethoxazole
Ibuprofen
Nafcillin
