A 63-year-old woman comes to the physician because of a 2-month history of blood in her urine. Cystoscopy shows transitional cell carcinoma of the bladder. Which of the following biopsy findings is most likely to warrant cystectomy in this patient?
Multifocal in situ transitional cell carcinoma
Non-invasive transitional cell carcinoma with 1:1 nuclear:cytoplasm ratio
Non-invasive transitional cell carcinoma with high Ki-67 index
Papillary transitional cell carcinoma with micro-invasion
Undifferentiated papillary transitional cell carcinoma
