A 60-year-old woman with a 40-pack-year history of smoking comes to the physician for a 2-week history of blood in her urine. Cystoscopy and biopsy shows transitional cell carcinoma of the bladder. Which of the following biopsy findings would suggest the poorest 5-year prognosis?
Carcinoma with microcalcification and copious rough endoplasmic reticulum
Carcinoma with poorly cohesive cells demonstrating prominent nucleoli
Poorly differentiated carcinoma with high Ki-67 index
Poorly differentiated carcinoma with 1:1 nuclear:cytoplasm ratio
Well-differentiated carcinoma with few mitoses and microinvasion
