A 4-year-old boy is brought to the physician for a 6-month history of recurrent otitis media and upper respiratory tract infections. He has history of cognitive impairment. Physical examination shows hepatosplenomegaly. Analysis of cutaneous fibroblasts shows inclusion bodies and deficiency of N-acetylglucosamine-1-phosphotransferase. Which of the following is most likely to be seen in this patient?
Increased dermatan and heparan sulfates
Increased glucocerebroside
Increased GM2 ganglioside
Increased serum acid hydrolases
Swollen rough endoplasmic reticulum
