A 3-day-old girl is brought to the physician because of vomiting throughout the night following breastfeeding. Physical examination shows dry mucous membranes and lethargy. Serum studies show:
Sodium 138 mEq/L
Potassium 6.5 mEq/L
Bicarbonate 18 mEq/L
Glucose 50 mg/dL
17-hydroxyprogesterone Increased
Which of the following is the most likely deficient enzyme in this patient?