A 66-year-old woman comes to the GP for a routine health examination. Her mother died of a myocardial infarction at age 52. Serum total cholesterol is 280 mg/dL, HDL cholesterol is 38 mg/dL, and LDL cholesterol is 210 mg/dL. Atorvastatin is commenced. This treatment is most likely to incite which of the following adaptive responses at the cellular level in this patient?
↓ HMG-CoA reductase translation
↑ HMG-CoA reductase transcription
↓ LDL receptor expression on hepatocytes
↑ Non-competitive inhibition of HMG-CoA reductase
↑ Ubiquitination of HMG-CoA reductase by endoplasmic reticulum-resident E3 ligases
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Cut-to-the-chase Answer (1:14):
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HY USMLE Answer (5:31):
