A 69-year-old man with heart failure is commenced on spironolactone. Which of the following is the most direct effect of administering this agent?
Decreased binding of aldosterone to its receptor in the cortical collecting duct
Decreased binding of aldosterone to its receptor in the medullary collecting duct
Decreased binding of angiotensin II to its receptor on vascular endothelium
Direct antagonism of aldosterone in plasma
Direct antagonism of aldosterone in plasma
Direct antagonism of angiotensin II in plasma
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Cut-to-the-chase Answer (0:58):
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HY USMLE Answer (4:07):
