Audio Qbank – Q213 – A 55F with weight loss

 

A 55-year-old woman comes to the physician because of a 9-kg (20-lb) weight loss the past two months. Physical examination shows pallor and a palpable spleen tip. Hemoglobin is 10 g/dL; hematocrit is 26%; leukocyte count is 5000/μL. Aspiration of bone marrow yields a dry tap. Which of the following is most likely to be seen in this patient?

 

t(9;22)
t(11;14)
t(11;22)
t(15;17)
JAK2 mutation

 

Cut-to-the-chase Answer (0:36):
HY USMLE Answer (4:02):