A 43-year-old man comes to the physician because of a painless right-sided neck mass for the past two weeks. He says that the mass appeared twice more earlier in the year, appearing to wax and wane over the course of a few weeks both times. Biopsy of a cervical lymph node shows cells in which the DNA does not form ladders of regularly shaped bands when treated with agents normally shown to upregulate intracellular caspases in control cell populations. This patient’s presentation is most likely due to increased expression of which of the following?
BCL2
BCR/ABL
CCND1
C-myc
EWSR1/FLI1
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Cut-to-the-chase Answer (0:47):
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HY USMLE Answer (6:46):