Audio Qbank – Q260 – A 20F with an enzyme deficiency

 

A 20-year-old woman presents to the physician because of a one-week history of fatigue. Laboratory studies show:

Hb 9.4 g/dL
Hct 28.2%
RBC 2,3-bisphosphoglycerate 9000 nmol/mL (N = 4100)
Bilirubin (total) 8 mg/dL
Bilirubin (indirect) 6.7 mg/dL

The patient’s blood smear is shown.

The deficient enzyme in this patient acts on which of the following substrates?

Acetyl-CoA
Lactate
Oxaloacetate
Phosphoenolpyruvate
Pyruvate
UDP-glucuronosyltransferase