A 68-year-old woman with back pain, renal amyloidosis, and hypercalcemia is commenced on bortezomib. Molecular studies indicate that this agent inhibits the 26S proteasome and causes downregulation of a cellular structure. An illustration of bortezomib bound to a proteasome core is shown.
Which of the following combinations of patient diagnosis and downregulated structure is most accurate?
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Cut-to-the-chase Answer (0:44):
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HY USMLE Answer (3:37):
