A 58-year-old woman comes to the physician because of a 4-month history of shortness of breath with exertion. There is an S4 heart sound on auscultation. Echocardiography shows normal ejection fraction. Laboratory studies show an increased ESR. A blood smear is shown.
Which of the following is the most likely direct explanation for these cardiac findings?
β2-microglobulin aggregation
Blast crisis
Lambda light chain deposition
Serum amyloid A protein aggregation
Plasma cell infiltration
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Cut-to-the-chase Answer (0:17):
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HY USMLE Answer (7:03):