Audio Qbank – Q283 – A 58F with shortness of breath

 

A 58-year-old woman comes to the physician because of a 4-month history of shortness of breath with exertion. There is an S4 heart sound on auscultation. Echocardiography shows normal ejection fraction. Laboratory studies show an increased ESR. A blood smear is shown.

Which of the following is the most likely direct explanation for these cardiac findings?

 

β2-microglobulin aggregation
Blast crisis
Lambda light chain deposition
Serum amyloid A protein aggregation
Plasma cell infiltration