A 17-year-old girl presents to the GP for a 3-month history of heavy menstrual flow. She has a history of epistaxis since childhood. Laboratory studies show:
Hemoglobin: 10.1 g/dL
Hematocrit: 30.3%
Platelet count: 240,000/μL
Bleeding time: 9 minutes
Prothrombin time: 14 seconds
Partial thromboplastin time: 35 seconds
Which of the following is the most likely mechanism for this patient’s condition?
Antibodies against glycoprotein Ib
Antibodies against glycoproteins IIb/IIIa
Congenital deficiency of glycoprotein Ib
Congenital deficiency of glycoproteins IIb/IIIa
Defective platelet adhesion
Defective platelet aggregation
Deficiency of factor VIII or IX
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Cut-to-the-chase Answer (0:40):
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HY USMLE Answer (8:44):
