A 42-year-old woman presents to the physician for a 6-month history of progressive fatigue and generalized pruritis. Vitals are within normal limits. Physical examination shows no abnormalities. Her brother has ulcerative colitis. Ultrasound is performed and shows a stone in the gallbladder. Laboratory studies are shown:
Hemoglobin: 9.8 g/dL
Alkaline phosphatase (ALP): 300 IU/L
Bilirubin (total): 2.0 mg/dL
Bilirubin (direct): 1.6 mg/dL
Which of the following autoantibodies is most likely to be seen in this patient?
ANCA (c)
ANCA (p)
Jo-1
Microsomal
Mitochondrial
Smooth muscle
Tissue transglutaminase IgA
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Cut-to-the-chase Answer (0:23):
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HY USMLE Answer (8:18):
