Audio Qbank – Q68 – A 44M with worsening shortness of breath

 

A 44-year-old man comes to the GP because of a 4-month history of worsening shortness of breath. Examination shows JVD and a loud P2. Spirometry shows an FEV1/FVC of 34% and a decreased DLCO. Which of the following is most likely decreased in this patient’s pulmonary vascular smooth muscle?

  Diacylglycerol

  Endothelin-1
  Nitric oxide synthase
  Thrombomodulin
  Vascular endothelial growth factor

Cut-to-the-chase Answer (0:36):

HY USMLE Answer (5:09):