An 8-year-old boy is brought to hospital 20 minutes after sudden-onset shortness of breath. He has had several similar episodes over the past few months. Vitals are: temperature 98.6F, HR 90, RR 26, BP 110/75. A sputum sample shows high numbers of eosinophils and Charcot-Leyden crystals. Which of the following chemical mediators is most likely involved in the pathogenesis of this patient’s condition?
IFN-gamma
IL-1
IL-10
Leukotriene D4
TNF-alpha
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Cut-to-the-chase Answer (0:50):
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HY USMLE Answer (4:24):