Endocrine pharm – Diabetes drugs

All material is copyrighted and the property of mehlmanmedical.

Copyright © mehlmanmedical.

Privacy Policy and Terms and Conditions


HY points about each drug followed by a quiz at the end

Insulin preparations

  • Insulin is the only treatment for type I diabetes (insulin deficiency).
  • Insulin is used last resort for type II diabetes (insulin resistance).
Insulin preparations
Type When after administration does peak effect occur? Name
Rapid-acting 1 hour LAG: Lispro, Aspart, Glulisine
Short-acting 2-3 hours Regular insulin
Intermediate-acting 4-10 hours NPH
Long-acting Detemir (6-12 hours); Glargine (no real peak) Detemir, Glargine

Quiz yourself:

Type II diabetes meds (oral hypoglycemics)

Metformin

MOA of metformin?

  • Inhibits mGPD (a mitochondrial enzyme called glycerophosphate dehydrogenase).
  • “Increases glycolysis and decreases gluconeogenesis” is the MOA answer on the USMLE.

Side-effects of metformin?

  • Lactic acidosis (HY)
    • Increased risk in patients with renal insufficiency.
    • 45M + T2DM + bicarb of 20 + creatinine of 1.6; next best step? –> answer = stop metformin.

Thiazolidinediones (pioglitazone, rosiglitazone)

MOA of thiazolidinediones?

  • Activate PPAR-α, leading to increased insulin sensitivity.

Side-effects of thiazolidinediones?

  • Heart failure
  • Weight gain
  • Edema

Sulfonylureas

  • First generation: Tolbutamide, Chlorpropamide
  • Second generation: Glyburide, Glipizide, Glibenclamide
  • Third generation: Glimepiride

MOA of sulfonylureas?

  • Insulin secretagogues (i.e., promote insulin release); require functioning beta-islet cells. If patient is on a sulfonylurea and his/her HbA1c is very high (e.g., 9+), it’s because he/she has most likely already has lost the beta-islet cells.
  • Close K+ channel on β-islet cells –> more K+ trapped in the cell –> cell depolarizes –> Ca2+ then enters cell –> insulin-containing vesicles are released from the cell.

Side-effects of sulfonylureas?

  • First generation: disulfiram-like reaction with EtOH.
  • Second + third generation: hypoglycemia (especially 2nd-gen glibenclamide).

Meglitinides (Repaglinide, Nateglinide)

MOA of meglitinides?

  • Same as sulfonylureas but structurally different.
  • Just know the MOA.

GLP-1 analogues (Liraglutide, Exenatide)

MOA of GLP-1 analogues?

  • ↓ glucagon release; ↑ glucose-dependent insulin release.
  • GLP-1 (glucagon-like peptide-1) is an endogenous GI hormone that suppresses glucagon release and increases insulin release in response to oral glucose.

Side-effects of GLP-1 analogues?

  • Pancreatitis

DPP-4 inhibitors (Linagliptin, Saxagliptin, Sitagliptin)

MOA of DPP-4 inhibitors?

  • DPP-4 is an enzyme that breaks down GLP-1.
  • Therefore the -gliptins help maintain levels of GLP-1.
  • Since GLP-1 ↓ glucagon release and ↑ glucose-dependent insulin release, DPP-4 inhibitors produce the same effect as the GLP-1 analogues liraglutide and exenatide.

SGLT-2 inhibitors (Dapagliflozin, Canagliflozin)

MOA of SGLT-2 inhibitors?

  • Inhibit sodium-glucose transporter 2 (SGLT-2), which normally reabsorbs glucose in the PCT of the kidney.
  • These agents decrease serum glucose by promoting glycosuria.

Side-effects of SGLT-2 inhibitors?

  • Increased risk of vulvovaginal candidiasis and UTIs (disruption of normal flora and pH balance).

α-glucosidase inhibitors (Acarbose, Miglitol)

MOA of α-glucosidase inhibitors?

  • Decrease small bowel absorption of glucose at the brush border, resulting in ↓ postprandial hyperglycemia.

Side-effects of α-glucosidase inhibitors?

  • Diarrhea

Amylin analogues (Pramlintide)

MOA of pramlintide?

  • Amylin is a peptide normally co-secreted with insulin. It inhibits glucagon secretion, delays gastric emptying, and promotes satiety.
  • It is deficient in type I diabetics (and late type II after the pancreas burns out).

1. MOA of metformin?

2. Side-effects of metformin?

3. a) Name two thiazolidinediones.

b) MOA of thiazolidinediones?

4. Side-effects of thiazolidinediones?

5. MOA of glyburide?

6. Side-effects of sulfonylureas?

7. MOA of repaglinide?

8. MOA of liraglutide?

9. MOA of linagliptin?

10. MOA of dapagliflozin?

11. Side-effects of SGLT-2 inhibitors?

12. Complete the following graph:

 
 

13. Complete the following table:

 
 

14. MOA of acarbose?

15. Side-effect of miglitol?

16. MOA of pramlintide?

17. a) Name a drug that inhibits SGLT-2.

b) Any side-effects of this drug?

18. What is amylin?

19. What is DPP-4?

20. What is GLP-1?

21. Sulfonylureas have the same MOA as which other class of agents?

22. Which class of diabetes drugs activates PPAR-α?

23. a) Which diabetes drug is notably contraindicated in renal insufficiency?

b) Why?