HY USMLE Q #1011 – Pathology

A 41-year-old man comes to the physician for a 3-month history of fatigue, generalized weakness, and bilateral hand pain. Physical examination shows hyperpigmentation of the skin of the forearms and hepatomegaly. X-ray of the hands shows chondrocalcinosis. Laboratory studies show fasting serum glucose of 112 mg/dL. Which of the following is the most likely explanation for this patient’s findings?

  Adrenal cortical hypersecretion
  Adrenal cortical hyposecretion
  β-islet cell glutamic acid decarboxylase-65 antibodies
  Excess cation absorption
  Multiple endocrine neoplasia

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